Pharmocokinetical study of Al- and Zn-sulphonated phthalocyanines

Natalia I. Kazachkina; Natalia N. Zharkova; Galina I. Fomina; Raisa I. Yakubovskaya; Victor V. Sokolov; Eugeny A. Lukyanets

doi:10.1117/12.260772

4 December 1996 Pharmocokinetical study of Al- and Zn-sulphonated phthalocyanines

Natalia I. Kazachkina, Natalia N. Zharkova, Galina I. Fomina, Raisa I. Yakubovskaya, Victor V. Sokolov, Eugeny A. Lukyanets

Author Affiliations +

Proceedings Volume 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II; (1996) https://doi.org/10.1117/12.260772
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

The comparative pharmacokinetical study of Al- and Zn- sulphonated phthalocyanines (AlPcS and ZnPcS, respectively) is the aim of the present work. Mice bearing solid Ehrlich tumor were used in this study. AlPcS (sodium salt) and ZnPcS (ammonium and sodium salts were used as photosensitizers. The photosensitizers were injected i/v in various doses. The exogenous fluorescence of tissues (tumor, liver, spleen, kidneys, muscles, skin) was measured dynamically after sensitization. It was shown that all of the photosensitizers under study had similar distribution pattern in organisms of mice and were selectively accumulated in the Ehrlich tumor tissue. The exogenous fluorescence intensity of tissues and it tumor:normal muscle ratio (Cs) depended on the dosage of the preparation, on the time, which had passed after drug injection, and on the stage of tumor growth. It was also shown that the kinetics of the tissue uptake of the studied sensitizers varied to some extent. Thus, the obtained data may be interesting for deeper understanding of the interaction of the dye with malignant tissues.

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Natalia I. Kazachkina, Natalia N. Zharkova, Galina I. Fomina, Raisa I. Yakubovskaya, Victor V. Sokolov, and Eugeny A. Lukyanets "Pharmocokinetical study of Al- and Zn-sulphonated phthalocyanines", Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); https://doi.org/10.1117/12.260772

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