Morphologic evaluations of Q-switched Nd:YAG laser injury of human retina

David K. Scales; Steven T. Schuschereba; David J. Lund; Bruce E. Stuck

doi:10.1117/12.275248

2 May 1997 Morphologic evaluations of Q-switched Nd:YAG laser injury of human retina

David K. Scales, Steven T. Schuschereba, David J. Lund, Bruce E. Stuck

Proceedings Volume 2974, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment; (1997) https://doi.org/10.1117/12.275248
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Depiction of the cellular and immune responses in the human model is critical to design rational therapies preventing/limiting cellular destruction and ultimately functional visual loss following acute laser injuries. We report the light and electron microscopy histologic findings in a controlled ocular human laser exposure. Following informed consent, the normal eye of a patient scheduled to undergo exenteration for invasive carcinoma of the orbit was exposed to both continuous wave and Q-switched lasers. Four hours prior to exenteration, argon G lesions were placed in the superior/temporal quadrant and Nd:YAG lesions were placed in the inferior/temporal quadrant. After enucleation, the retina was prepared for routine light and transmission electron microscopy. Histology of the argon G lesions showed primarily photoreceptor and RPE photocoagulation damage. Neutrophil adhesion was limited within the choroid and no neutrophils were observed in the subretinal space. In contrast, the 4 hr Nd:YAG lesions showed extensive retinal disruption, hemorrhage within subretinal and intraretinal spaces, neutrophil accumulation in the retina, and an extensive neutrophil chemotaxic and emigration response in the choroid. Severe laser injuries elicit a significant neutrophil response by 4 hr, suggesting that neutrophils should be an early stage therapeutic target.

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David K. Scales, Steven T. Schuschereba, David J. Lund, and Bruce E. Stuck "Morphologic evaluations of Q-switched Nd:YAG laser injury of human retina", Proc. SPIE 2974, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment, (2 May 1997); https://doi.org/10.1117/12.275248

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KEYWORDS

Injuries

Nd:YAG lasers

Argon

Retina

Electron microscopy

Q switched lasers

Q switching

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