Experimental study and first clinical results with a cooled applicator system for interstitial laser coagulation (LITT)

Andre Roggan; Verena Knappe; Martin G. Mack; Thomas J. Vogl; Dirk Albrecht; Christoph-Thomas Germer; Joerg-Peter Ritz; F. Kniep; Gerhard J. Mueller

doi:10.1117/12.304354

2 April 1998 Experimental study and first clinical results with a cooled applicator system for interstitial laser coagulation (LITT)

Andre Roggan, Verena Knappe, Martin G. Mack, Thomas J. Vogl, Dirk Albrecht, Christoph-Thomas Germer, Joerg-Peter Ritz, F. Kniep, Gerhard J. Mueller

Author Affiliations +

Proceedings Volume 3249, Surgical Applications of Energy; (1998) https://doi.org/10.1117/12.304354
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Laser-induced interstitial thermotherapy has proven to be an effective method for the treatment of different types of tumors. Until now the attainable coagulation volume was limited by the maximum applicable energy. The limiting factor was the high tissue temperature around the applicator which may have caused applicator damage. Consequently an internally cooled catheter system has been developed in order to reduce the temperature of the applicator surface and to allow for the application of higher laser powers. The optimal treatment parameters for the Nd:YAG laser were determined on the basis of in vitro studies with porcine tissue. Following these experimental studies, 127 patients with liver metastases were treated with the cooled system. The applicator position and the resulting tissue damage were verified using a MRI on-line monitoring system applying a FLASH-2D sequence. The optimal in vivo treatment parameters were found to be 25 watts for an exposure time of 20 minutes, resulting in coagulated volumes of up to 20 cm³. The experimental and clinical results have proven that the combination of a scattering laser applicator with an internally flushed catheter enables a significant increase in the coagulation volume.

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Andre Roggan, Verena Knappe, Martin G. Mack, Thomas J. Vogl, Dirk Albrecht, Christoph-Thomas Germer, Joerg-Peter Ritz, F. Kniep, and Gerhard J. Mueller "Experimental study and first clinical results with a cooled applicator system for interstitial laser coagulation (LITT)", Proc. SPIE 3249, Surgical Applications of Energy, (2 April 1998); https://doi.org/10.1117/12.304354

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