Feasibility of frequency domain NIR spectrometer to measure fetal cerebral blood oxygenation in utero

Re-Gine Choe; Gargi Vishnoi; Nirmala Ramanujam; Vasilis Ntziachristos; Shoko Nioka; Britton Chance; Arjun G. Yodh; Martha E. Rode; Iraj Forouzan; Mark Morgan

doi:10.1117/12.356782

15 July 1999 Feasibility of frequency domain NIR spectrometer to measure fetal cerebral blood oxygenation in utero

Re-Gine Choe, Gargi Vishnoi, Nirmala Ramanujam, Vasilis Ntziachristos, Shoko Nioka, Britton Chance, Arjun G. Yodh, Martha E. Rode, Iraj Forouzan, Mark Morgan

Author Affiliations +

Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999) https://doi.org/10.1117/12.356782
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

We present a preliminary assessment of the feasibility of using a frequency domain spectrometer for measuring fetal cerebral blood oxygenation in-utero at 750 and 780 nm of modulation at 70 MHz. The amplitude and phase of the diffuse photon density wave which propagates through the tissue is detected by a photomultiplier tube. The absorption coefficient ?a and the reduced scattering coefficient ?'s are calculated based on the analytic solution of the photon diffusion equation for a semi-infinite geometry. The accuracy of the instrument and the algorithm in measuring ?a is tested by an experiment performed on a homogeneous ink/intralipid tissue phantom. Also the sensitivity of the system to the change of blood volume and oxgenation is evaluated through a homogeneous blood/intralipid tissue phantom experiment. Clinical data was recorded during the elective Cesarean section of human subjects. The measurements were made on maternal abdomen in the post-epidural stage and on the fontanel region of neonate before (pre-cord) and after (post-cord) the umbilical cord was detached. The source detector separation used were 7 and 3(or 4) cm respectively. The deoxygenated and oxygenated hemoglobin concentration, blood volume and saturation were calculated based on ?a of 2 wavelength. The averaged optical properties and blood parameters for each stage are presented. The post-epidural blood saturation value correlates well with the pre-cord saturation value. A larger number of human subjects are being evaluated to provide statistically significant results.

Citation Download Citation

Re-Gine Choe, Gargi Vishnoi, Nirmala Ramanujam, Vasilis Ntziachristos, Shoko Nioka, Britton Chance, Arjun G. Yodh, Martha E. Rode, Iraj Forouzan, and Mark Morgan "Feasibility of frequency domain NIR spectrometer to measure fetal cerebral blood oxygenation in utero", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); https://doi.org/10.1117/12.356782

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available