Free-electron laser effects on fibrin tissue glue: a preliminary study

Karen Margaret Joos M.D.; Katie Topadze; Charles Shieh; Jin-Hui Shen; Vivien A. Casagrande

doi:10.1117/12.387516

7 June 2000 Free-electron laser effects on fibrin tissue glue: a preliminary study

Karen Margaret Joos M.D., Katie Topadze, Charles Shieh, Jin-Hui Shen, Vivien A. Casagrande

Proceedings Volume 3908, Ophthalmic Technologies X; (2000) https://doi.org/10.1117/12.387516
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

One glaucoma challenge is the treatment of leaking trabeculectomy blebs. Simple methods such as patching, autologous blood injection, compression sutures or cyanoacrylate glue application often fail. Because the conjunctiva is thin and ischemic, it often can't be sutured together so major surgery is required to excise the thin tissue and advance healthy conjunctiva. We report the preliminary results of Tisseel and Tisseel treated with two wavelengths from Vanderbilt's free electron laser placed on leaking trabeculectomy bleb holes in Dutch belted rabbits. The holes were healed at one week in the sutured group and in the 7.7 micrometer FEL-treated Tisseel group. One hole was healed in the cyanoacrylate glue-treated group. Holes remained in the other treatment groups. Tisseel irradiated with 7.7 micrometer energy from the free electron laser may promote healing of trabeculectomy bleb holes.

Citation Download Citation

Karen Margaret Joos M.D., Katie Topadze, Charles Shieh, Jin-Hui Shen, and Vivien A. Casagrande "Free-electron laser effects on fibrin tissue glue: a preliminary study", Proc. SPIE 3908, Ophthalmic Technologies X, (7 June 2000); https://doi.org/10.1117/12.387516

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