Peculiarities of lymph flow in microvessels

Ekateryna I. Galanzha; Gregory E. Brill; Sergey S. Ulyanov; Valery V. Tuchin; Anastasiya V. Solov'eva; Alexey V. Sedykh

doi:10.1117/12.387135

31 May 2000 Peculiarities of lymph flow in microvessels

Ekateryna I. Galanzha, Gregory E. Brill, Sergey S. Ulyanov, Valery V. Tuchin, Anastasiya V. Solov'eva, Alexey V. Sedykh

Proceedings Volume 3923, Optical Diagnostics of Biological Fluids V; (2000) https://doi.org/10.1117/12.387135
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

In the present study the characteristics of lymph flow in microvessels are investigated in vivo by the speckle- interferometrical and biomicroscopic methods. Two parameters of the lymph flow velocity are determined. The first frequency-weighted spectral moment of Doppler signal (M₁) was calculated. This parameter is proportional to lymph flow velocity. In the same regions of lymphatics the velocity of translational motion of the signal lymphocytes in the flow is assessed. The value of velocity and the parameter M₁ essentially varied. The temporary dynamics of M₁ indicated that the lymph flow had the alternating- translational character. Simultaneously the diameter of lymph microvessel, the amplitude and the rate of phasic contraction and the rate of valve functioning are registered. N^G-nitro-L-arginine (L-NNA, 10^-4 M), an inhibitor of nitric oxide synthase, is topically applied during 15 min. The application of L-NNA provoked the modulation of alternating-translational motion of lymph flow, the changes of diameters and rate of valve function and the stimulating of phasic contractions and the correlation between parameters of lymph microcirculation.

Citation Download Citation

Ekateryna I. Galanzha, Gregory E. Brill, Sergey S. Ulyanov, Valery V. Tuchin, Anastasiya V. Solov'eva, and Alexey V. Sedykh "Peculiarities of lymph flow in microvessels", Proc. SPIE 3923, Optical Diagnostics of Biological Fluids V, (31 May 2000); https://doi.org/10.1117/12.387135

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