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An optical fiber needle probe was developed that can be inserted into a hollow metallic needle for tumor diagnosis using fluorescence at key wavelengths for breast, kidney, liver, and brain. The optical fiber needle probe is based on fluorescence ration method which will allow to detect tumor in vivo for a real time evaluation. This method will be couple with other current modalities such as X-ray, ultrasound and MRI.
Gui Chen Tang,Alvin Katz,Yury Budansky, andRobert R. Alfano
"Optic fiber needle to probe inside the body using fluorescence ratio method", Proc. SPIE 4082, Optical Sensing, Imaging, and Manipulation for Biological and Biomedical Applications, (4 July 2000); https://doi.org/10.1117/12.390537
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Gui Chen Tang, Alvin Katz, Yury Budansky, Robert R. Alfano, "Optic fiber needle to probe inside the body using fluorescence ratio method," Proc. SPIE 4082, Optical Sensing, Imaging, and Manipulation for Biological and Biomedical Applications, (4 July 2000); https://doi.org/10.1117/12.390537