Promotion of PDT efficacy by bile acids

Michelle Castelli; John Reiners Jr.; David Kessel

doi:10.1117/12.473615

13 June 2003 Promotion of PDT efficacy by bile acids

Michelle Castelli, John Reiners Jr., David Kessel

Proceedings Volume 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII; (2003) https://doi.org/10.1117/12.473615
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

We had previously described the use of relatively hydrophobic bile acids, notably UDCA (ursodeoxycholate) for the promotion of the apoptotic response to photodynamic therapy. Further study revealed that this effect occurred only when the target for photodamage was the anti-apoptotic protein Bcl-2. The efficacy of lysosomal photodamage, leading to a cleavage of the protein Bid, was not influenced by UDCA. Moreover, the apoptotic cell death resulting from treatment of cells with the non-peptidic Bcl-2 inhibitor HA 14-1 was also promoted by UDCA. These results are consistent with the proposal that the pro-apoptotic effects of UDCA are directed against Bcl-2, promoting inactivation by HA 14-1 or photodamage.

Citation Download Citation

Michelle Castelli, John Reiners Jr., and David Kessel "Promotion of PDT efficacy by bile acids", Proc. SPIE 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII, (13 June 2003); https://doi.org/10.1117/12.473615

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