Spatio-temporal characteristics of cerebral blood volume changes in different microvascular compartments evoked by sciatic nerve stimulation in rat somatosensory cortex

Pengcheng Li; Qingming Luo; Weihua Luo; Shangbin Chen; Haiying Chen; Shaoqun Zeng

doi:10.1117/12.518783

13 October 2003 Spatio-temporal characteristics of cerebral blood volume changes in different microvascular compartments evoked by sciatic nerve stimulation in rat somatosensory cortex

Pengcheng Li, Qingming Luo, Weihua Luo, Shangbin Chen, Haiying Chen, Shaoqun Zeng

Author Affiliations +

Proceedings Volume 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV; (2003) https://doi.org/10.1117/12.518783
Event: Saratov Fall Meeting 2002 Laser Physics and Photonics, Spectroscopy, and Molecular Modeling III; Coherent Optics of Ordered and Random Media III, 2002, Saratov, Russian Federation

Abstract

The spatio-temporal characteristics of changes in cerebral blood volume associated with neuronal activity were investigated in the hindlimb somatosensory cortex of α-chloralose/urethan anesthetized rats (n=10) with optical imaging at 570nm through a thinned skull. Activation of cortex was carried out by electrical stimulation of the contralateral sciatic nerve with 5Hz, 0.3V pulses (0.5ms) for duration of 2s. The stimulation evoked a monophasic optical reflectance decrease at cortical parenchyma and arteries sites rapidly after the onset of stimulation, whereas no similar response was observed at vein compartments. The optical signal changes reached 10% of the peak response 0.70±0.32s after stimulation onset and no significant time lag in this 10% start latency time was observed between the response at cortical parenchyma and arteries compartments. The evoked optical reflectance decrease reached the peak (0.25%±0.047%)2.66±0.61s after the stimulus onset at parenchyma site, 0.40±0.20s earlier (P<0.05) than that at arteries site (0.50%±0.068% 3.06±0.70s). Variable location within the cortical parenchyma and arteries compartment themselves didn’t affect the temporal characteristics of the evoked signal significantly. These results suggest that the sciatic nerve stimulation evokes a local blood volume increase at both capillaries (cortical parenchyma) and arterioles rapidly after the stimulus onset but the evoked blood volume increase in capillaries could not be entirely accounted for by the dilation of arterioles.

Citation Download Citation

Pengcheng Li, Qingming Luo, Weihua Luo, Shangbin Chen, Haiying Chen, and Shaoqun Zeng "Spatio-temporal characteristics of cerebral blood volume changes in different microvascular compartments evoked by sciatic nerve stimulation in rat somatosensory cortex", Proc. SPIE 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV, (13 October 2003); https://doi.org/10.1117/12.518783

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Blood

Nerve

Arteries

Capillaries

Optical imaging

Reflectivity

Somatosensory cortex

Show All Keywords

Keywords/Phrases

Search In:

Publication Years