Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states

Alexander I. Kholodnykh; Kamran Hosseini; Kirill V. Larin; Alexandra A. Vassilieva; Rinat O. Esenaliev; Massoud Motamedi

doi:10.1117/12.533356

1 July 2004 Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states

Alexander I. Kholodnykh, Kamran Hosseini, Kirill V. Larin, Alexandra A. Vassilieva, Rinat O. Esenaliev, Massoud Motamedi

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Proceedings Volume 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII; (2004) https://doi.org/10.1117/12.533356
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Recently we reported measurements of the corneal in-depth light backscattering distribution (CDLBD) by optical coherence tomography (OCT) as a possible tool for investigation of the corneal hydration and estimation of water gradients inside the cornea. In this paper, we present additional results demonstrating a strong correlation (R = 0.99) between the amplitude of light backscattering as measured by OCT and the corneal thickness. In contrary to the well-known effect of the immediate increase observed in corneal opacity during corneal swelling, we observed an initial decrease of the amplitude of light backscattering as measured by OCT in the anterior part of the stroma during the swelling process. The possible explanation for this observation is discussed. Also methodological improvements for accurate measurements of the CDLBD in vivo are outlined.

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Alexander I. Kholodnykh, Kamran Hosseini, Kirill V. Larin, Alexandra A. Vassilieva, Rinat O. Esenaliev, and Massoud Motamedi "Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states", Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); https://doi.org/10.1117/12.533356

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KEYWORDS

Backscatter

Optical coherence tomography

Cornea

Eye

In vivo imaging

Confocal microscopy

Interfaces

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