Noninvasive glucose sensing in scattering media using OCT, PAS, and TOF techniques

Erkki Alarousu; Jukka T. Hast; Matti T. Kinnunen; Mikhail Yu. Kirillin; Risto A. Myllyla; Jerzy Plucinski; Alexey P. Popov; Alexander V. Priezzhev; Tuukka Prykari; Juha Saarela; Zuomin Zhao

doi:10.1117/12.578321

20 August 2004 Noninvasive glucose sensing in scattering media using OCT, PAS, and TOF techniques

Erkki Alarousu, Jukka T. Hast, Matti T. Kinnunen, Mikhail Yu. Kirillin, Risto A. Myllyla, Jerzy Plucinski, Alexey P. Popov, Alexander V. Priezzhev, Tuukka Prykari, Juha Saarela, Zuomin Zhao

Author Affiliations +

Proceedings Volume 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V; (2004) https://doi.org/10.1117/12.578321
Event: Saratov Fall Meeting 2003, 2003, Saratov, Russian Federation

Abstract

In this paper, optical measurement techniques, which enable non-invasive measurement, are superimposed to glucose sensing in scattering media. Used measurement techniques are Optical Coherence Tomography (OCT), Photoacoustic spectroscopy (PAS) and laser pulse Time-of-Flight (TOF) measurement using a streak camera. In parallel with measurements, a Monte-Carlo (MC) simulation models have been developed. Experimental in vitro measurements were performed using Intralipid fat emulsion as a tissue simulating phantom for OCT and TOF measurements. In PAS measurements, a pork meat was used as a subject but also preliminary in vivo measurements were done. OCT measurement results show that the slope of the OCT signal's envelope changes as a function of glucose content in the scattering media. TOF measurements show that the laser pulse full width of half maximum (FWHM) changes a little as function of glucose content. An agreement with MC-simulations and measurements with Intralipid was also found. Measurement results of PAS technique show that changes in glucose content in the pork meat tissue can be measured. In vivo measurements with a human volunteer show that other factors such as physiological change, blood circulation and body temperature drift may interfere the PA response of glucose.

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Erkki Alarousu, Jukka T. Hast, Matti T. Kinnunen, Mikhail Yu. Kirillin, Risto A. Myllyla, Jerzy Plucinski, Alexey P. Popov, Alexander V. Priezzhev, Tuukka Prykari, Juha Saarela, and Zuomin Zhao "Noninvasive glucose sensing in scattering media using OCT, PAS, and TOF techniques", Proc. SPIE 5474, Saratov Fall Meeting 2003: Optical Technologies in Biophysics and Medicine V, (20 August 2004); https://doi.org/10.1117/12.578321

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