The susceptibility of bacteria to photodynamic inactivation with lanthanide complexes of chlorin e6

Artur Bednarkiewicz; Zuzanna Drulis-Kawa; Rafal Wiglusz; Janina Legendziewicz; Gabriela Bugla-Ploskonska; Wlodzimierz Doroszkiewicz; Manfred Haupt; Wieslaw Strek

doi:10.1117/12.633092

26 August 2005 The susceptibility of bacteria to photodynamic inactivation with lanthanide complexes of chlorin e6

Artur Bednarkiewicz, Zuzanna Drulis-Kawa, Rafal Wiglusz, Janina Legendziewicz, Gabriela Bugla-Ploskonska, Wlodzimierz Doroszkiewicz, Manfred Haupt, Wieslaw Strek

Author Affiliations +

Proceedings Volume 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II; 58630V (2005) https://doi.org/10.1117/12.633092
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

Photodynamic inactivation (PDI) may be a very promising alternative method for antimicrobial treatment of many localised infections. In the present study we report the activity of three lanthanides (Eu(III), Pr(III), Yb(III)) complexes of Fotolon sensitizer, composed of chlorin e6 and polyvinylpyrrolidone (PVP), against standard E.coli P. aeruginosa, K. pneumoniae and S. aureus ATCC strains. The 160±10mW/cm² of 651 nm laser light was applied for 600 seconds after photosensitiser administration (50μg/ml) and 30 minutes incubation time. Impact of pure Fotolon and pure lanthanides solution was examined as control groups.

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Artur Bednarkiewicz, Zuzanna Drulis-Kawa, Rafal Wiglusz, Janina Legendziewicz, Gabriela Bugla-Ploskonska, Wlodzimierz Doroszkiewicz, Manfred Haupt, and Wieslaw Strek "The susceptibility of bacteria to photodynamic inactivation with lanthanide complexes of chlorin e6", Proc. SPIE 5863, Therapeutic Laser Applications and Laser-Tissue Interactions II, 58630V (26 August 2005); https://doi.org/10.1117/12.633092

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KEYWORDS

Lanthanides

Bacteria

Antimicrobial agents

Biomedical optics

Fourier transforms

Laser applications

Laser therapeutics

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