Photothermal effect in the tissue during photodynamic therapy

Zhongming Li; Zhenxi Zhang

doi:10.1117/12.667131

2 February 2006 Photothermal effect in the tissue during photodynamic therapy

Zhongming Li, Zhenxi Zhang

Proceedings Volume 6026, ICO20: Biomedical Optics; 60260G (2006) https://doi.org/10.1117/12.667131
Event: ICO20:Optical Devices and Instruments, 2005, Changchun, China

Abstract

Based on the Pennes' bio-heat transfer equation, temperature distribution in the tissue during PDT is analyzed in theory. The study indicates that laser heat source could be formed in tissue during laser irradiation, which results in the temperature rising in one-dimensional space. The rising of tissue temperature increases in exponent with time and decreases in exponent with the distance from laser irradiation position.. There exists a minimal light dosage threshold during the photothermal interaction between laser and bio-tissue. When the light dosage is lower than the critical threshold, the laser irradiation will not produce thermal effect. The threshold dosage, which depends on the optical and thermal properties of bio-tissue, increases in exponent with the distance from laser irradiating point along the direction of incident light.

Citation Download Citation

Zhongming Li and Zhenxi Zhang "Photothermal effect in the tissue during photodynamic therapy", Proc. SPIE 6026, ICO20: Biomedical Optics, 60260G (2 February 2006); https://doi.org/10.1117/12.667131

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