Threshold damage of in vivo porcine skin at 2000 nm laser irradiation

Bo Chen; Daniel C. O'Dell; Sharon L. Thomsen; Benjamin A Rockwell; Ashley J. Welch

doi:10.1117/12.639069

28 February 2006 Threshold damage of in vivo porcine skin at 2000 nm laser irradiation

Bo Chen, Daniel C. O'Dell, Sharon L. Thomsen, Benjamin A Rockwell, Ashley J. Welch

Proceedings Volume 6084, Optical Interactions with Tissue and Cells XVII; 60840C (2006) https://doi.org/10.1117/12.639069
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

A series of experiments were conducted in vivo on female Yucatan mini-pigs to determine the ED₅₀ damage thresholds for 2000 nm continuous wave laser irradiation. These results provide new information for refinement of Maximum Permissible Exposure (MPE). The study employed Gaussian laser beam exposures with spot diameters (1/e²) of 4.83 mm, 9.65 mm and 14.65 mm and exposure durations of 0.25 s, 0.5 s, 1.0 s and 2.5 seconds as a function of laser power. The effect of each irradiation was evaluated within one minute after irradiation and the final determination was made at 48 hours post exposure. Probit analysis was conducted to estimate the dose for 50% probability of laser-induced damage (ED₅₀) defined as persistent redness at the site of irradiation for the mini-pig skin after 48 hours. Histopathologic procedures were used to determine the mechanisms of the laser effects in the skin and map the extent and severity of the lesions. The thresholds study shows that consideration for lowering the current Maximum Permissible Exposure (MPE) limits should be explored as the laser beam diameter becomes larger than 3.5 mm. Based on the limited experimental data, the duration and size dependences of the ED₅₀ damage thresholds could be described by an empirical equation: (Equation available in manuscript.)

Citation Download Citation

Bo Chen, Daniel C. O'Dell, Sharon L. Thomsen, Benjamin A Rockwell, and Ashley J. Welch "Threshold damage of in vivo porcine skin at 2000 nm laser irradiation", Proc. SPIE 6084, Optical Interactions with Tissue and Cells XVII, 60840C (28 February 2006); https://doi.org/10.1117/12.639069

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available