Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves

Mitsuhiro Terakawa; Shunichi Sato; Daizoh Saitoh; Hitoshi Tsuda; Hiroshi Ashida; Hideyuki Okano; Minoru Obara

doi:10.1117/12.700215

19 February 2007 Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves

Mitsuhiro Terakawa, Shunichi Sato, Daizoh Saitoh, Hitoshi Tsuda, Hiroshi Ashida, Hideyuki Okano, Minoru Obara

Author Affiliations +

Proceedings Volume 6435, Optical Interactions with Tissue and Cells XVIII; 643513 (2007) https://doi.org/10.1117/12.700215
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

We delivered a therapeutic gene, hepatocyte growth factor (HGF), to skin grafts of rats using laser-induced stress waves (LISWs) with the objective of enhancing their adhesion. The density and uniformity of neovascularities were enhanced significantly in the grafted skins that were transfected using LISWs, suggesting the efficacy of this method to improve the outcome of skin transplantation.

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Mitsuhiro Terakawa, Shunichi Sato, Daizoh Saitoh, Hitoshi Tsuda, Hiroshi Ashida, Hideyuki Okano, and Minoru Obara "Enhanced angiogenesis in grafted skins by gene transfer of human hepatocyte growth factor using laser-induced stress waves", Proc. SPIE 6435, Optical Interactions with Tissue and Cells XVIII, 643513 (19 February 2007); https://doi.org/10.1117/12.700215

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