Time-resolved scanning system for double reflectance and transmittance fluorescence imaging of small animals

Marco Brambilla; Lorenzo Spinelli; Antonio Pifferi; Alessandro Torricelli; Rinaldo Cubeddu

doi:10.1117/12.727883

11 July 2007 Time-resolved scanning system for double reflectance and transmittance fluorescence imaging of small animals

Marco Brambilla, Lorenzo Spinelli, Antonio Pifferi, Alessandro Torricelli, Rinaldo Cubeddu

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Proceedings Volume 6626, Molecular Imaging; 66260L (2007) https://doi.org/10.1117/12.727883
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

We developed a time-resolved scanning system for fluorescence molecular imaging in diffusive media, such as biological tissues. In the present work the system is described and characterized in terms of linearity against optical parameters of the sample and against homogeneously diffuse fluorescent dye. Finally, preliminary measurements performed on phantom are presented, pointing out the ability of our system to produce projective images of the fluorophore distribution into the sample with a 200 fmol sensitivity and to decouple fluorescent amplitude from depth by means of fluorescent transmittance imaging.

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Marco Brambilla, Lorenzo Spinelli, Antonio Pifferi, Alessandro Torricelli, and Rinaldo Cubeddu "Time-resolved scanning system for double reflectance and transmittance fluorescence imaging of small animals", Proc. SPIE 6626, Molecular Imaging, 66260L (11 July 2007); https://doi.org/10.1117/12.727883

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KEYWORDS

Luminescence

Transmittance

Imaging systems

Reflectivity

Molecular imaging

Optical properties

Optical filters

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