The exploration of the characteristics of the hyperglycemia serum fluorescence spectrum

Lexin Wang; Zhimin Zhao; Hui Chen; Peng Li; Yujun Xin

doi:10.1117/12.806410

2 February 2009 The exploration of the characteristics of the hyperglycemia serum fluorescence spectrum

Lexin Wang, Zhimin Zhao, Hui Chen, Peng Li, Yujun Xin

Proceedings Volume 7160, 2008 International Conference on Optical Instruments and Technology: Optoelectronic Measurement Technology and Applications; 71601M (2009) https://doi.org/10.1117/12.806410
Event: International Conference of Optical Instrument and Technology, 2008, Beijing, China

Abstract

Now, spectra technology is widely used in the biomedicine research,so this study investigates variation of the fluorescence spectra in different excitation wavelength, and the spectra of serum with different glucose concentration is tested in the excitation wavelength of 240nm to 280nm. The experimental result shows that the correlation between the serum fluorescence intensity and the excitation light is very close, when the excitation light is in the ultraviolet wave band, the fluorescence of serum is intensive. There is a violent fluorescence emission wavelength, which is 300nm to 410nm, while the excitation wavelength ranges from 220nm to 290nm, and the peaks wavelength are 330nm and 370nm. From 240nm to 280nm, the serum fluorescence intensity increases synchronously with the glucose concentration, and the relationship between the fluorescence peak wavelength and the glucose concentration is almost in line. In this way the blood sugar concentration can be estimated by the fluorescence spectra peak wavelength when the excitation wavelength is from 240nm to 280nm, which is effective. It provides experimental foundation for the wide use of spectra technology in medical diagnose, and the effectiv method to test the blood sugar concentration.

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Lexin Wang, Zhimin Zhao, Hui Chen, Peng Li, and Yujun Xin "The exploration of the characteristics of the hyperglycemia serum fluorescence spectrum", Proc. SPIE 7160, 2008 International Conference on Optical Instruments and Technology: Optoelectronic Measurement Technology and Applications, 71601M (2 February 2009); https://doi.org/10.1117/12.806410

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KEYWORDS

Luminescence

Blood

Glucose

Ultraviolet radiation

Absorption

Diagnostics

Lithium

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