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23 February 2009 A novel fast imaging modality for free radicals in vivo: continuous wave (CW) EPR imaging with direct detection and rapid field scan in the presence of rotating gradients
Sankaran Subramanian, Janusz W. Koscielniak, Nallathamby Devasahayam, Ghadi Salem, Randall H. Pursley, Thomas J. Pohida, Murali C. Krishna
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Proceedings Volume 7170, Design and Quality for Biomedical Technologies II; 717008 (2009) https://doi.org/10.1117/12.809280
Event: SPIE BiOS, 2009, San Jose, California, United States
Abstract
The work described in this presentation relates to a novel approach to Electron Paramagnetic Resonance imaging in vivo. The method employs a continuous wave approach to spectral detection without the conventional low frequency modulation and phase sensitive detection. A combination of direct detection and rapid field scan in the simultaneous presence of rotating gradients enables imaging with high temporal resolution. Since CW detection is not limited to free radical spin probes with narrow spectral lines, unlike the time-domain case, this novel approach uniquely accomplishes ultra fast functional imaging and is applicable to common redox-sensitive spin probes without line-width restriction.
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Sankaran Subramanian, Janusz W. Koscielniak, Nallathamby Devasahayam, Ghadi Salem, Randall H. Pursley, Thomas J. Pohida, and Murali C. Krishna "A novel fast imaging modality for free radicals in vivo: continuous wave (CW) EPR imaging with direct detection and rapid field scan in the presence of rotating gradients", Proc. SPIE 7170, Design and Quality for Biomedical Technologies II, 717008 (23 February 2009); https://doi.org/10.1117/12.809280
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KEYWORDS
Signal detection
In vivo imaging
Tumors
Frequency modulation
3D image processing
Amplifiers
Oxygen
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