A novel optical-fiber based surface plasmon resonance sensing architecture and its application to gastric cancer diagnostics

Alexandre Francois; Jonathan Boehm; Megan Penno; Peter Hoffmann; Tanya M Monro

doi:10.1117/12.885066

17 May 2011 A novel optical-fiber based surface plasmon resonance sensing architecture and its application to gastric cancer diagnostics

Alexandre Francois, Jonathan Boehm, Megan Penno, Peter Hoffmann, Tanya M Monro

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Proceedings Volume 7753, 21st International Conference on Optical Fiber Sensors; 77536Y (2011) https://doi.org/10.1117/12.885066
Event: 21st International Conference on Optical Fibre Sensors (OFS21), 2011, Ottawa, Canada

Abstract

The management of threats such as pandemics and explosives, and of health and the environment requires the rapid deployment of highly sensitive detection tools. Sensors based on Surface Plasmon Resonance (SPR) allow rapid, labelfree, highly sensitive detection, and indeed this phenomenon underpins the only label-free optical biosensing technology that is available commercially. In these sensors, the existence of surface plasmons is inferred indirectly from absorption features that correspond to the coupling of light to the surface plasmon. Although SPR is not intrinsically a radiative process, under certain conditions the surface plasmon can itself couple to the local photon states, and emit light. Here we show for the first time that by collecting and characterising this re-emitted light, it is possible to realise new SPR sensing architectures that are more compact, versatile and robust than existing approaches. It is applicable to a range of SPR geometries, including optical fibres. As an example, this approach has been used to demonstrate the detection of a protein identified as a being a biomarker for cancer.

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Alexandre Francois, Jonathan Boehm, Megan Penno, Peter Hoffmann, and Tanya M Monro "A novel optical-fiber based surface plasmon resonance sensing architecture and its application to gastric cancer diagnostics", Proc. SPIE 7753, 21st International Conference on Optical Fiber Sensors, 77536Y (17 May 2011); https://doi.org/10.1117/12.885066

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KEYWORDS

Surface plasmons

Sensors

Silver

Cancer

Fiber optics sensors

Optical fibers

Proteins

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