Photoacoustic and nuclear imaging of [125I]-labeled gold nanorod contrast agent

Xia Shao; Ashish Agarwal; Justin R. Rajian; Nicholas A. Kotov; Xueding Wang

doi:10.1117/12.875604

18 February 2011 Photoacoustic and nuclear imaging of [¹²⁵I]-labeled gold nanorod contrast agent

Xia Shao, Ashish Agarwal, Justin R. Rajian, Nicholas A. Kotov, Xueding Wang

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 789924 (2011) https://doi.org/10.1117/12.875604
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We have investigated the potential of emerging photoacoustic imaging and nuclear imaging in monitoring of drug delivery by using a newly developed dual-modality contrast agent. After the contrast agent composed of gold nanorods (GNRs) was produced, it was radiolabeled by [¹²⁵I] with high yield and without disturbing the optical properties of the contrast agent. Photoacoustic and nuclear imaging were conducted to visualize the distribution of GNRs in articular tissues of rat tail joints in situ. Findings from the two modalities corresponded well with each other. Using the current imaging systems, GNRs down to a concentration of 10 pM in biological tissues and with a radioactive label of 5 μCi can be imaged. Moreover, by radiolabeling the GNRs, the in vivo behaviors of the contrast agent can be monitored conveniently using γ-camera, allowing validation of the findings from emerging photoacoustic technique. Enabled by the high sensitivity of nuclear imaging, whole-body and longitudinal studies of the biodistribution of GNRs contrast agent can be performed noninvasively and repeatedly in the same animal. The highly efficient method reported here provides an extensively useful tool for the guidance of design and development of new gold nanoparticles as target-specific agents for both diagnostics and therapy.

Citation Download Citation

Xia Shao, Ashish Agarwal, Justin R. Rajian, Nicholas A. Kotov, and Xueding Wang "Photoacoustic and nuclear imaging of [¹²⁵I]-labeled gold nanorod contrast agent", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 789924 (18 February 2011); https://doi.org/10.1117/12.875604

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