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Molecularly imprinted polymer (MIP) thin films and surface plasmon resonance (SPR) sensing technologies were
combined to develop a novel sensing platform for monitoring real-time theophylline concentration, which is a compound
of interest in environmental monitoring and a molecular probe for phenotyping certain cytochrome P450 enzymes. The
MIPs hydrogel is easy to synthesize and provides shape-selective recognition with high affinity to specific target
molecules. Different polymerization formulas were tested and optimized. The influence of the monomer sensitive factors
were addressed by SPR. SPR is an evanescent wave optics based sensing technique that is suitable for real-time and label
free sensing purposes. Gold nanorods (Au NRs) were uniformly immobilized onto a SPR sensing surface for the
construction of a fiber optics based prism-free localized SPR (LSPR) measurement. This technique can be also applied to
assess the activities of other small organic molecules by adjusting the polymerization formula, thus, this approach also
has many other potential applications.
Rui Zheng andBrent D. Cameron
"Development of a molecularly imprinted polymer based surface plasmon resonance sensor for theophylline monitoring", Proc. SPIE 7911, Plasmonics in Biology and Medicine VIII, 79110F (12 February 2011); https://doi.org/10.1117/12.875312
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Rui Zheng, Brent D. Cameron, "Development of a molecularly imprinted polymer-based surface plasmon resonance sensor for theophylline monitoring," Proc. SPIE 7911, Plasmonics in Biology and Medicine VIII, 79110F (12 February 2011); https://doi.org/10.1117/12.875312