Dynamic focus optical coherence tomography: feasibility for improved basal cell carcinoma investigation

M. R. Nasiri-Avanaki; Ahmed Aber; S. A. Hojjatoleslami; Mano Sira; John B. Schofield; Carole Jones; A. Gh. Podoleanu

doi:10.1117/12.912081

9 February 2012 Dynamic focus optical coherence tomography: feasibility for improved basal cell carcinoma investigation

M. R. Nasiri-Avanaki, Ahmed Aber, S. A. Hojjatoleslami, Mano Sira, John B. Schofield, Carole Jones, A. Gh. Podoleanu

Proceedings Volume 8225, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X; 82252J (2012) https://doi.org/10.1117/12.912081
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Basal cell carcinoma (BCC) is the most common form of skin cancer. To improve the diagnostic accuracy, additional non-invasive methods of making a preliminary diagnosis have been sought. We have implemented an En-Face optical coherence tomography (OCT) for this study in which the dynamic focus was integrated into it. With the dynamic focus scheme, the coherence gate moves synchronously with the peak of confocal gate determined by the confocal interface optics. The transversal resolution is then conserved throughout the depth range and an enhanced signal is returned from all depths. The Basal Cell Carcinoma specimens were obtained from the eyelid a patient. The specimens under went analysis by DF-OCT imaging. We searched for remarkable features that were visualized by OCT and compared these findings with features presented in the histology slices.

Citation Download Citation

M. R. Nasiri-Avanaki, Ahmed Aber, S. A. Hojjatoleslami, Mano Sira, John B. Schofield, Carole Jones, and A. Gh. Podoleanu "Dynamic focus optical coherence tomography: feasibility for improved basal cell carcinoma investigation", Proc. SPIE 8225, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues X, 82252J (9 February 2012); https://doi.org/10.1117/12.912081

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