Polyion complex micelles incorporating poly (aryl benzyl ether) dendritic phthalocyanine: effective photosensitizers for enhanced photodynamic therapy

Kuizhi Chen; Ming Yu; Hong Zhang; Dongdong Ma; Shujuan Pang; Wei Huang; Yiru Peng

doi:10.1117/12.2001194

11 December 2012 Polyion complex micelles incorporating poly (aryl benzyl ether) dendritic phthalocyanine: effective photosensitizers for enhanced photodynamic therapy

Kuizhi Chen, Ming Yu, Hong Zhang, Dongdong Ma, Shujuan Pang, Wei Huang, Yiru Peng

Author Affiliations +

Proceedings Volume 8553, Optics in Health Care and Biomedical Optics V; 85532C (2012) https://doi.org/10.1117/12.2001194
Event: Photonics Asia, 2012, Beijing, China

Abstract

A novel series of zinc (II) phthalocyanines bearing four poly (aryl benzyl ether) dendritic substituents with carboxylic acid functionalities (G_n-DPcZn (G_n=n-generation dendrimer, n=1-2)) loaded polymeric micelles (G_n-DPcZn/m) were formed. The time-dependent intracellular uptake of G_n-DPcZn in RPE cells increased as they were incorporated into micelles, but inversely correlated with the generation. The photocytoxity of G_n-DPcZn was improved by incorporation into polymeric micelles and increased with the generation.

Citation Download Citation

Kuizhi Chen, Ming Yu, Hong Zhang, Dongdong Ma, Shujuan Pang, Wei Huang, and Yiru Peng "Polyion complex micelles incorporating poly (aryl benzyl ether) dendritic phthalocyanine: effective photosensitizers for enhanced photodynamic therapy", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85532C (11 December 2012); https://doi.org/10.1117/12.2001194

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