Use of functional near-infrared spectroscopy to monitor cortical plasticity induced by transcranial direct current stimulation

Bilal Khan; Nathan Hervey; Ann Stowe; Timea Hodics; George Alexandrakis

doi:10.1117/12.2003446

8 March 2013 Use of functional near-infrared spectroscopy to monitor cortical plasticity induced by transcranial direct current stimulation

Bilal Khan, Nathan Hervey, Ann Stowe, Timea Hodics, George Alexandrakis

Author Affiliations +

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 856560 (2013) https://doi.org/10.1117/12.2003446
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Electrical stimulation of the human cortex in conjunction with physical rehabilitation has been a valuable approach in facilitating the plasticity of the injured brain. One such method is transcranial direct current stimulation (tDCS) which is a non-invasive method to elicit neural stimulation by delivering current through electrodes placed on the scalp. In order to better understand the effects tDCS has on cortical plasticity, neuroimaging techniques have been used pre and post tDCS stimulation. Recently, neuroimaging methods have discovered changes in resting state cortical hemodynamics after the application of tDCS on human subjects. However, analysis of the cortical hemodynamic activity for a physical task during and post tDCS stimulation has not been studied to our knowledge. A viable and sensitive neuroimaging method to map changes in cortical hemodynamics during activation is functional near-infrared spectroscopy (fNIRS). In this study, the cortical activity during an event-related, left wrist curl task was mapped with fNIRS before, during, and after tDCS stimulation on eight healthy adults. Along with the fNIRS optodes, two electrodes were placed over the sensorimotor hand areas of both brain hemispheres to apply tDCS. Changes were found in both resting state cortical connectivity and cortical activation patterns that occurred during and after tDCS. Additionally, changes to surface electromyography (sEMG) measurements of the wrist flexor and extensor of both arms during the wrist curl movement, acquired concurrently with fNIRS, were analyzed and related to the transient cortical plastic changes induced by tDCS.

Citation Download Citation

Bilal Khan, Nathan Hervey, Ann Stowe, Timea Hodics, and George Alexandrakis "Use of functional near-infrared spectroscopy to monitor cortical plasticity induced by transcranial direct current stimulation", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 856560 (8 March 2013); https://doi.org/10.1117/12.2003446

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