Optical characterization of two-layered tissue-like phantoms using multi-distance, frequency domain near-infrared spectroscopy

Bertan Hallacoglu; Angelo Sassaroli; Sergio Fantini

doi:10.1117/12.2002453

25 March 2013 Optical characterization of two-layered tissue-like phantoms using multi-distance, frequency domain near-infrared spectroscopy

Bertan Hallacoglu, Angelo Sassaroli, Sergio Fantini

Author Affiliations +

Proceedings Volume 8578, Optical Tomography and Spectroscopy of Tissue X; 85780B (2013) https://doi.org/10.1117/12.2002453
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We present a near-infrared spectroscopy (NIRS) approach for the optical characterization of two-layered tissuemimicking phantoms. For the data acquisition, we employed a multi-distance frequency-domain system. For the data analysis, we implemented an inversion routine based on a two-layered solution of the frequency-domain diffusion equation as the forward model. Measured quantities were the absorption and reduced scattering coefficients of the first layer (μ_a1, μ’_s1) and the second layer (μ_a2, μ’_s2), and the thickness of the first layer (L). We report measurements on three two-layered liquid phantoms featuring absorption coefficients in the range 0.009-0.017 mm^-1, reduced scattering coefficients in the range 0.69-0.92 mm^-1, and first layer thickness in the range 8-15 mm. Our method yielded measured values of the optical coefficients and first layer thickness (μ_a1, μ’_s1, μ_a2, μ’_s2, and L) that are within 10% of the true values (optical properties measured in the infinite geometry; and the true first layer thickness). These are promising results toward exploring the potential of this two-layered medium approach in the human head, where the two layers would represent extracerebral and cerebral tissue, respectively.

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Bertan Hallacoglu, Angelo Sassaroli, and Sergio Fantini "Optical characterization of two-layered tissue-like phantoms using multi-distance, frequency domain near-infrared spectroscopy", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85780B (25 March 2013); https://doi.org/10.1117/12.2002453

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KEYWORDS

Tissue optics

Optical testing

Near infrared spectroscopy

Optical properties

Absorption

Data modeling

Diffusion

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