Effects of La0.2Ce0.6Eu0.2F3 nanocrystals capped with polyethylene glycol on human pancreatic cancer cells in vitro

Nathan J. Withers; Natasha N. Glazener; Antonio C. Rivera; Brian A. Akins; Leisha M. Armijo; John B. Plumley; Nathaniel C. Cook; Jacqueline M. Sugar; Rana Chan; Yekaterina I. Brandt; Gennady A. Smolyakov; Philip H. Heintz; Marek Osiński

doi:10.1117/12.2009468

22 February 2013 Effects of La_0.2Ce_0.6Eu_0.2F₃ nanocrystals capped with polyethylene glycol on human pancreatic cancer cells in vitro

Nathan J. Withers, Natasha N. Glazener, Antonio C. Rivera, Brian A. Akins, Leisha M. Armijo, John B. Plumley, Nathaniel C. Cook, Jacqueline M. Sugar, Rana Chan, Yekaterina I. Brandt, Gennady A. Smolyakov, Philip H. Heintz, Marek Osiński

Author Affiliations +

Proceedings Volume 8595, Colloidal Nanocrystals for Biomedical Applications VIII; 85951O (2013) https://doi.org/10.1117/12.2009468
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Lanthanide fluoride colloidal nanocrystals offer a way to improve the diagnosis and treatment of cancer through the enhanced absorption of ionizing radiation, in addition to providing visible luminescence. In order to explore this possibility, tests with a kilovoltage therapy unit manufactured by the Universal X-Ray Company were performed to estimate the energy sensitivity of this technique. La_0.2Ce_0.6Eu_0.2F₃ nanocrystals capped with polyethylene glycol of molecular weight 6000 were synthesized, suspended in deionized water, and made tolerant to biological ionic pressures by incubation with fetal bovine serum. These nanocrystals were characterized by dynamic light scattering, muffle furnace ashing, and photoluminescence spectroscopy. Clonogenic assays were performed on the cells to assay the cytotoxicity and radiotoxicity of the nanocrystals on the human pancreatic cancer cell line PANC-1, purchased from ATCC.

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Nathan J. Withers, Natasha N. Glazener, Antonio C. Rivera, Brian A. Akins, Leisha M. Armijo, John B. Plumley, Nathaniel C. Cook, Jacqueline M. Sugar, Rana Chan, Yekaterina I. Brandt, Gennady A. Smolyakov, Philip H. Heintz, and Marek Osiński "Effects of La_0.2Ce_0.6Eu_0.2F₃ nanocrystals capped with polyethylene glycol on human pancreatic cancer cells in vitro", Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 85951O (22 February 2013); https://doi.org/10.1117/12.2009468

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