Characteristics of chiral and racemic ketoprofen drugs using terahertz time-domain spectroscopy

Yong Du; Jianjun Liu; Zhi Hong

doi:10.1117/12.2033147

23 August 2013 Characteristics of chiral and racemic ketoprofen drugs using terahertz time-domain spectroscopy

Yong Du, Jianjun Liu, Zhi Hong

Proceedings Volume 8909, International Symposium on Photoelectronic Detection and Imaging 2013: Terahertz Technologies and Applications; 89090M (2013) https://doi.org/10.1117/12.2033147
Event: ISPDI 2013 - Fifth International Symposium on Photoelectronic Detection and Imaging, 2013, Beijing, China

Abstract

Absorption spectra of chiral S-(+)- and racemic RS-ketoprofen pharmaceutical molecules in crystalline form were recorded in the terahertz region between 6 and 66 cm^-1 (0.2 ~ 2.0 THz) by using time-domain terahertz spectroscopic (THz-TDS) measurement. Different distinctive absorption features were observed which are strikingly sensitive to the change of subtle conformational structures within such isostructural crystal molecules. The results suggest that the THz-TDS technique can be definitely used for distinguishing between chiral and racemic compounds in pharmaceutical and biological fields.

Citation Download Citation

Yong Du, Jianjun Liu, and Zhi Hong "Characteristics of chiral and racemic ketoprofen drugs using terahertz time-domain spectroscopy", Proc. SPIE 8909, International Symposium on Photoelectronic Detection and Imaging 2013: Terahertz Technologies and Applications, 89090M (23 August 2013); https://doi.org/10.1117/12.2033147

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available