Reference-tissue correction of T2-weighted signal intensity for prostate cancer detection

Yahui Peng; Yulei Jiang; Aytekin Oto

doi:10.1117/12.2043585

24 March 2014 Reference-tissue correction of T₂-weighted signal intensity for prostate cancer detection

Yahui Peng, Yulei Jiang, Aytekin Oto

Proceedings Volume 9035, Medical Imaging 2014: Computer-Aided Diagnosis; 903508 (2014) https://doi.org/10.1117/12.2043585
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

The purpose of this study was to investigate whether correction with respect to reference tissue of T₂-weighted MRimage signal intensity (SI) improves its effectiveness for classification of regions of interest (ROIs) as prostate cancer (PCa) or normal prostatic tissue. Two image datasets collected retrospectively were used in this study: 71 cases acquired with GE scanners (dataset A), and 59 cases acquired with Philips scanners (dataset B). Through a consensus histology- MR correlation review, 175 PCa and 108 normal-tissue ROIs were identified and drawn manually. Reference-tissue ROIs were selected in each case from the levator ani muscle, urinary bladder, and pubic bone. T₂-weighted image SI was corrected as the ratio of the average T₂-weighted image SI within an ROI to that of a reference-tissue ROI. Area under the receiver operating characteristic curve (AUC) was used to evaluate the effectiveness of T₂-weighted image SIs for differentiation of PCa from normal-tissue ROIs. AUC (± standard error) for uncorrected T₂-weighted image SIs was 0.78±0.04 (datasets A) and 0.65±0.05 (datasets B). AUC for corrected T₂-weighted image SIs with respect to muscle, bladder, and bone reference was 0.77±0.04 (p=1.0), 0.77±0.04 (p=1.0), and 0.75±0.04 (p=0.8), respectively, for dataset A; and 0.81±0.04 (p=0.002), 0.78±0.04 (p<0.001), and 0.79±0.04 (p<0.001), respectively, for dataset B. Correction in reference to the levator ani muscle yielded the most consistent results between GE and Phillips images. Correction of T₂-weighted image SI in reference to three types of extra-prostatic tissue can improve its effectiveness for differentiation of PCa from normal-tissue ROIs, and correction in reference to the levator ani muscle produces consistent T₂-weighted image SIs between GE and Phillips MR images.

Citation Download Citation

Yahui Peng, Yulei Jiang, and Aytekin Oto "Reference-tissue correction of T₂-weighted signal intensity for prostate cancer detection", Proc. SPIE 9035, Medical Imaging 2014: Computer-Aided Diagnosis, 903508 (24 March 2014); https://doi.org/10.1117/12.2043585

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available