Morpho-chemistry and functionality of diseased biological tissues

Marta Lange; Riccardo Cicchi; Francesco Pavone

doi:10.1117/12.2060813

5 September 2014 Morpho-chemistry and functionality of diseased biological tissues

Marta Lange, Riccardo Cicchi, Francesco Pavone

Proceedings Volume 9198, Ultrafast Nonlinear Imaging and Spectroscopy II; 919802 (2014) https://doi.org/10.1117/12.2060813
Event: SPIE Optical Engineering + Applications, 2014, San Diego, California, United States

Abstract

Heart and cardiovascular diseases are one of the most common in the world, in particular – arthrosclerosis. The aim of the research is to distinguish pathological and healthy tissue regions in biological samples, in this case – to distinguish collagen and lipid rich regions within the arterial wall. In the work a specific combination of such methods are used: FLIM and SHG in order to evaluate the biological tissue morphology and functionality, so that this research could give a contribution for creating a new biological tissue imaging standard in the closest future. During the study the most appropriate parameter for fluorescence lifetime decay was chosen in order to evaluate lifetime decay parameters and the isotropy of the arterial wall and deposition, using statistical methods FFT and GLCM. The research gives a contribution or the future investigations for evaluating lipid properties when it can de-attach from the arterial wall and cause clotting in the blood vessel or even a stroke.

Citation Download Citation

Marta Lange, Riccardo Cicchi, and Francesco Pavone "Morpho-chemistry and functionality of diseased biological tissues", Proc. SPIE 9198, Ultrafast Nonlinear Imaging and Spectroscopy II, 919802 (5 September 2014); https://doi.org/10.1117/12.2060813

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