In-situ photopolymerization and monitoring device for controlled shaping of tissue fillers, replacements, or implants

Andreas M. Schmocker; Azadeh Khoushabi; Pierre-Etienne Bourban; Constantin Schizas; Dominique Pioletti; Christophe Moser

doi:10.1117/12.2076680

4 March 2015 In-situ photopolymerization and monitoring device for controlled shaping of tissue fillers, replacements, or implants

Andreas M. Schmocker, Azadeh Khoushabi, Pierre-Etienne Bourban, Constantin Schizas, Dominique Pioletti, Christophe Moser

Author Affiliations +

Proceedings Volume 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII; 93130C (2015) https://doi.org/10.1117/12.2076680
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Photopolymerization is a common tool to harden materials initially in a liquid state. A surgeon can directly trigger the solidification of a dental implant or a bone or tissue filler simply by illumination. Traditionally, photopolymerization has been used mainly in dentistry. Over the last decade advances in material development including a wide range of biocompatible gel- and cement-systems open up a new avenue for in-situ photopolymerization.

However, at the device level, surgical endoscopic probes are required. We present a miniaturized light probe where a photoactive material can be 1) mixed, pressurized and injected 2) photopolymerized or photoactivated and 3) monitored during the chemical reaction. The device enables surgeries to be conducted through a hole smaller than 1 mm in diameter.

Beside basic injection mechanics, the tool consists of an optical fiber guiding the light required for photopolymerization and for chemical analysis. Combining photorheology and fluorescence spectroscopy, the current state of the photopolymerization is inferred and monitored in real time. Biocompatible and highly tuneable Poly-Ethylene-Glycol (PEG) hydrogels were used as the injection material.

The device was tested on a model for intervertebral disc replacement. Gels were successfully implanted into a bovine caudal model and mechanically tested in-vitro during two weeks. The photopolymerized gel was evaluated at the tissue level (adherence and mechanical properties of the implant), at the cellular level (biocompatibility and cytotoxicity) and ergonomic level (sterilization procedure and feasibility study).

This paper covers the monitoring aspect of the device.

Citation Download Citation

Andreas M. Schmocker, Azadeh Khoushabi, Pierre-Etienne Bourban, Constantin Schizas, Dominique Pioletti, and Christophe Moser "In-situ photopolymerization and monitoring device for controlled shaping of tissue fillers, replacements, or implants", Proc. SPIE 9313, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII, 93130C (4 March 2015); https://doi.org/10.1117/12.2076680

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available