Retrieving small features in reflection-mode raster-scan optoacoustic mesoscopy (RSOM) using multi-frequency reconstruction

Murad Omar; Dominik Soliman; Jérôme Gateau; Vasilis Ntziachristos

doi:10.1117/12.2076717

11 March 2015 Retrieving small features in reflection-mode raster-scan optoacoustic mesoscopy (RSOM) using multi-frequency reconstruction

Murad Omar, Dominik Soliman, Jérôme Gateau, Vasilis Ntziachristos

Author Affiliations +

Proceedings Volume 9323, Photons Plus Ultrasound: Imaging and Sensing 2015; 932326 (2015) https://doi.org/10.1117/12.2076717
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

We developed a reflection-mode, raster-scan optoacoustic mesoscopy system, based on a custom-made ultrasonic detector, with an ultra wide bandwidth of 20-180 MHz. To optimally use this bandwidth, we implemented multifrequency reconstruction. System characterization reveals a 4 μm axial, and 18 μm transverse resolution, at penetration depths reaching 5 mm. After characterization, the system was applied to image a zebrafish ex vivo, and an excised mouse ear. In the zebrafish, the lateral line, intestines, eyes, and melanocytes are seen, while in the mouse ear, multi-frequency reconstruction recovered the small vessels, otherwise not seen on the image.

Citation Download Citation

Murad Omar, Dominik Soliman, Jérôme Gateau, and Vasilis Ntziachristos "Retrieving small features in reflection-mode raster-scan optoacoustic mesoscopy (RSOM) using multi-frequency reconstruction", Proc. SPIE 9323, Photons Plus Ultrasound: Imaging and Sensing 2015, 932326 (11 March 2015); https://doi.org/10.1117/12.2076717

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