Performance comparison of breast imaging modalities using a 4AFC human observer study

Premkumar Elangovan; Alaleh Rashidnasab; Alistair Mackenzie; David R. Dance; Kenneth C. Young; Hilde Bosmans; William P. Segars; Kevin Wells

doi:10.1117/12.2081878

18 March 2015 Performance comparison of breast imaging modalities using a 4AFC human observer study

Premkumar Elangovan, Alaleh Rashidnasab, Alistair Mackenzie, David R. Dance, Kenneth C. Young, Hilde Bosmans, William P. Segars, Kevin Wells

Author Affiliations +

Proceedings Volume 9412, Medical Imaging 2015: Physics of Medical Imaging; 94121T (2015) https://doi.org/10.1117/12.2081878
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

This work compares the visibility of spheres and simulated masses in 2D-mammography and tomosynthesis systems using human observer studies. Performing comparison studies between breast imaging systems poses a number of practical challenges within a clinical environment. We therefore adopted a simulation approach which included synthetic breast blocks, a validated lesion simulation model and a set of validated image modelling tools as a viable alternative to clinical trials. A series of 4-alternative forced choice (4AFC) human observer experiments has been conducted for signal detection tasks using masses and spheres as targets. Five physicists participated in the study viewing images with a 5mm target at a range of contrast levels and 60 trials per experimental condition. The results showed that tomosynthesis has a lower threshold contrast than 2D-mammography for masses and spheres, and that detection studies using spheres may produce overly-optimistic threshold contrast values.

Citation Download Citation

Premkumar Elangovan, Alaleh Rashidnasab, Alistair Mackenzie, David R. Dance, Kenneth C. Young, Hilde Bosmans, William P. Segars, and Kevin Wells "Performance comparison of breast imaging modalities using a 4AFC human observer study", Proc. SPIE 9412, Medical Imaging 2015: Physics of Medical Imaging, 94121T (18 March 2015); https://doi.org/10.1117/12.2081878

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