An interventional multispectral photoacoustic imaging platform for the guidance of minimally invasive procedures

Wenfeng Xia; Daniil I. Nikitichev; Jean Martial Mari; Simeon J. West; Sebastien Ourselin; Paul C. Beard; Adrien E. Desjardins

doi:10.1117/12.2183798

16 July 2015 An interventional multispectral photoacoustic imaging platform for the guidance of minimally invasive procedures

Wenfeng Xia, Daniil I. Nikitichev, Jean Martial Mari, Simeon J. West, Sebastien Ourselin, Paul C. Beard, Adrien E. Desjardins

Author Affiliations +

Proceedings Volume 9539, Opto-Acoustic Methods and Applications in Biophotonics II; 95390D (2015) https://doi.org/10.1117/12.2183798
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

Precise and eﬃcient guidance of medical devices is of paramount importance for many minimally invasive procedures. These procedures include fetal interventions, tumor biopsies and treatments, central venous catheterisations and peripheral nerve blocks. Ultrasound imaging is commonly used for guidance, but it often provides insuﬃcient contrast with which to identify soft tissue structures such as vessels, tumors, and nerves. In this study, a hybrid interventional imaging system that combines ultrasound imaging and multispectral photoacoustic imaging for guiding minimally invasive procedures was developed and characterized. The system provides both structural information from ultrasound imaging and molecular information from multispectral photoacoustic imaging. It uses a commercial linear-array ultrasound imaging probe as the ultrasound receiver, with a multimode optical fiber embedded in a needle to deliver pulsed excitation light to tissue. Co-registration of ultrasound and photoacoustic images is achieved with the use of the same ultrasound receiver for both modalities. Using tissue ex vivo, the system successfully discriminated deep-located fat tissue from the surrounding muscle tissue. The measured photoacoustic spectrum of the fat tissue had good agreement with the lipid spectrum in literature.

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Wenfeng Xia, Daniil I. Nikitichev, Jean Martial Mari, Simeon J. West, Sebastien Ourselin, Paul C. Beard, and Adrien E. Desjardins "An interventional multispectral photoacoustic imaging platform for the guidance of minimally invasive procedures", Proc. SPIE 9539, Opto-Acoustic Methods and Applications in Biophotonics II, 95390D (16 July 2015); https://doi.org/10.1117/12.2183798

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