Comparative studies of the effects of copper sulfate and zinc sulfate on serum albumins

O. A. Plotnikova; G. V. Melnikov; A. G. Melnikov; A. V. Kovalenko

doi:10.1117/12.2229603

21 April 2016 Comparative studies of the effects of copper sulfate and zinc sulfate on serum albumins

O. A. Plotnikova, G. V. Melnikov, A. G. Melnikov, A. V. Kovalenko

Proceedings Volume 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS); 99170Z (2016) https://doi.org/10.1117/12.2229603
Event: Saratov Fall Meeting 2015, 2015, Saratov, Russian Federation

Abstract

The work is devoted to the study of the interaction of heavy metals with bovine serum albumin (BSA) and human serum albumin (HSA), by quenching of the intrinsic fluorescence of proteins and fluorescent probe pyrene by heavy metal ions. Sulfates of copper and zinc (CuSO4, ZnSO4) were taken as the metal salts. The value of the Stern-Volmer constants of quenching of intrinsic fluorescence of proteins and fluorescence probe pyrene reduced from Cu (II) to the Zn (II). It was experimentally found that the copper ions have a greater ability to fluorescence quenching, which is probably associated with the greater availability of protein chromophore groups to copper ions and with adsorbed fluorescent probe pyrene in the protein globule.

Citation Download Citation

O. A. Plotnikova, G. V. Melnikov, A. G. Melnikov, and A. V. Kovalenko "Comparative studies of the effects of copper sulfate and zinc sulfate on serum albumins", Proc. SPIE 9917, Saratov Fall Meeting 2015: Third International Symposium on Optics and Biophotonics and Seventh Finnish-Russian Photonics and Laser Symposium (PALS), 99170Z (21 April 2016); https://doi.org/10.1117/12.2229603

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