Photoreceptors are the primary sensing element of the human visual system. Traditionally, photoreceptors are imaged with hardware-based adaptive optics (AO), which compensate for eye aberrations. However, these systems can be challenging to maintain. Here, we demonstrate the spatiotemporal optical coherence tomography
(STOC-T) as the new modality for high-speed, cellular-level volumetric imaging of the human retina in vivo. The cellular features become visible after applying digital aberration corrections. We also show that STOC-T provides cross-sectional images (B-scans) and, concurrently, high-resolution wide-field en face images of the inner and outer human retina layers.
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