Clinical translation of intracranial pressure sensing with diffuse correlation spectroscopy

Syeda M. Tabassum; Alexander Ruesch; Deepshikha Acharya; Jason Yang; Jaskaran Rakkar; Robert S. B. Clark; Michael M. McDowell; Jana M Kainerstorfer

doi:10.1117/12.2610429

7 March 2022 Clinical translation of intracranial pressure sensing with diffuse correlation spectroscopy

Syeda M. Tabassum, Alexander Ruesch, Deepshikha Acharya, Jason Yang, Jaskaran Rakkar, Robert S. B. Clark, Michael M. McDowell, Jana M Kainerstorfer

Author Affiliations +

Proceedings Volume PC11945, Clinical and Translational Neurophotonics 2022; PC119450A (2022) https://doi.org/10.1117/12.2610429
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Current standard-of-care methods for measuring intracranial pressure (ICP) are highly invasive. To overcome this limitation, we recently demonstrated non-invasive quantification of ICP in an animal model using morphological analysis of the pulsatile cerebral blood flow (CBF) measured with Diffuse Correlation Spectroscopy. Here, we present results from a pilot study in pediatric patients admitted to an intensive care unit. We show that the CBF pulsatile waveform changes with ICP. Using a regression forest-based machine learning algorithm on a cohort of patients (n>15) we demonstrate that ICP extraction in humans can be possible, suggesting the potential for successful clinical translation in future.

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Citation Download Citation

Syeda M. Tabassum, Alexander Ruesch, Deepshikha Acharya, Jason Yang, Jaskaran Rakkar, Robert S. B. Clark, Michael M. McDowell, and Jana M Kainerstorfer "Clinical translation of intracranial pressure sensing with diffuse correlation spectroscopy", Proc. SPIE PC11945, Clinical and Translational Neurophotonics 2022, PC119450A (7 March 2022); https://doi.org/10.1117/12.2610429

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