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7 March 2022 Computational modeling of photomechanical effects during infrared neural stimulation
Mayna H. Nguyen, Chad A. Oian, Anita Mahadevan-Jansen, E. Duco Jansen
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Proceedings Volume PC11947, Optogenetics and Optical Manipulation 2022; PC1194707 (2022) https://doi.org/10.1117/12.2607633
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Infrared neural stimulation (INS) is a label-free method that uses infrared light to excite neural tissue. Because the biophysical mechanism of INS is not fully understood, we present a computational modeling study demonstrating photomechanical effects in a rat sciatic nerve from infrared pulses across a range of pulse widths. By comparing the resulting pressure and displacement across different pulse widths, this allows for insight of the sensitivity of the photomechanical effects from laser irradiation. Additionally, a further look into the initial spike of the Ho:YAG laser shows that a photomechanical component could possibly explain the lower stimulation threshold.
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Mayna H. Nguyen, Chad A. Oian, Anita Mahadevan-Jansen, and E. Duco Jansen "Computational modeling of photomechanical effects during infrared neural stimulation", Proc. SPIE PC11947, Optogenetics and Optical Manipulation 2022, PC1194707 (7 March 2022); https://doi.org/10.1117/12.2607633
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KEYWORDS
Computational modeling
Infrared photography
Infrared radiation
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