Aging of deep venous thrombosis using polarization sensitive optical coherence tomography

Georgia Thomas; Hassan Albadawi; Rahmi Oklu; Lida Hariri; Brett Bouma; Martin Villiger

doi:10.1117/12.2609207

9 March 2022 Aging of deep venous thrombosis using polarization sensitive optical coherence tomography

Georgia Thomas, Hassan Albadawi, Rahmi Oklu, Lida Hariri, Brett Bouma, Martin Villiger

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Proceedings Volume PC11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX; PC119490M (2022) https://doi.org/10.1117/12.2609207
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Deep venous thrombosis is a global health problem with significant complications and high recurrence. Supporting the search for more effective therapies, polarization-sensitive optical coherence tomography (PS-OCT) may offer diagnostic imaging to determine the age of thrombus and personalize treatment. To assess sensitivity to thrombus aging, the IVC of two rat cohorts were imaged in-vivo at 24 hours (acute) or 28 days (chronic) after thrombus creation. The PS-OCT metrics were capable of differentiating acute and chronic thrombi with 98.2% total accuracy. These results demonstrate that PS-OCT is sensitive to structural changes in thrombi and could help guide advanced thrombolytic therapies.

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Georgia Thomas, Hassan Albadawi, Rahmi Oklu, Lida Hariri, Brett Bouma, and Martin Villiger "Aging of deep venous thrombosis using polarization sensitive optical coherence tomography", Proc. SPIE PC11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX, PC119490M (9 March 2022); https://doi.org/10.1117/12.2609207

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KEYWORDS

Optical coherence tomography

Polarization

Therapeutics

In vivo imaging

Birefringence

Collagen

Image analysis

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