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7 March 2022 Label-free measurement of human cells biophysical properties with a methodology combining microfluidic devices and digital holographic microscopy
Erik Bélanger, Gabrielle Jess, Sara Mattar, Mohamed Haouat, Émile Rioux-Péllerin, Marie-Ève Crochetière, Jean-Xavier Giroux, Pierre Marquet
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Proceedings Volume PC11955, Microfluidics, BioMEMS, and Medical Microsystems XX; PC1195505 (2022) https://doi.org/10.1117/12.2610473
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Biophysical properties (BPs) of a cell depend drastically on its physiological or pathological state. Thus, being able to accurately and non-invasively measure a set of cell BPs, that reflect these cellular states, is of major importance. To this end, we propose an approach that combines customized fluidic devices with digital holographic microscopy (DHM). Specifically, we have developed several low-cost 3D-printed millifluidic devices which when combined with DHM allow to measure in a controlled physiological environment specific cell BPs including intracellular refractive index, absolute cell volume, membrane flickering as well as cell elasticity and viscosity moduli.
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Erik Bélanger, Gabrielle Jess, Sara Mattar, Mohamed Haouat, Émile Rioux-Péllerin, Marie-Ève Crochetière, Jean-Xavier Giroux, and Pierre Marquet "Label-free measurement of human cells biophysical properties with a methodology combining microfluidic devices and digital holographic microscopy", Proc. SPIE PC11955, Microfluidics, BioMEMS, and Medical Microsystems XX, PC1195505 (7 March 2022); https://doi.org/10.1117/12.2610473
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KEYWORDS
Digital holography
Microfluidics
Holography
Microscopy
Microfluidic imaging
Control systems
Environmental sensing
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