Lisa Kobayashi Frisk,1 Manish Verma,1 Chen-Hao P. Lin,2 Sumana Chetiahttps://orcid.org/0000-0003-1574-8153,1 Faruk Beslija,1 Jason Trobaugh,2 Joseph P. Culver,3,4 Turgut Durduran1,5
1ICFO - Institut de Ciències Fotòniques (Spain) 2Washington Univ. in St. Louis (United States) 3Department of Physics, Washington University in Saint Louis (United States) 4Department of Radiology, Washington University School of Medicine (United States) 5Institució Catalana de Recerca i Estudis Avançats (Spain)
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A variety of diffuse optical methods use laser speckle contrast and its statistics to non-invasively determine blood flow. In most cases, this implies very low detected count-rates which leads to systematic errors in determining the correct speckle statistics. We have developed a comprehensive method for simulating realistic speckle contrast resultant from light propagation in tissue taking into account experimental and fundamental sources of noise. Results of the simulation are used to determine the relationship of these parameters on the precision and accuracy of the speckle contrast signal.
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Lisa Kobayashi Frisk, Manish Verma, Chen-Hao P. Lin, Sumana Chetia, Faruk Beslija, Jason Trobaugh, Joseph P. Culver, Turgut Durduran, "Modelling the experimental and fundamental signal-to-noise in speckle contrast optical tomography," Proc. SPIE PC11959, Dynamics and Fluctuations in Biomedical Photonics XIX, PC1195907 (2 March 2022); https://doi.org/10.1117/12.2610256