Alberto Sinibaldi,1 Vanessa Montano-Machado,2 Norbert Danz,3 Peter Munzert,3 Francesco Chiavaiolihttps://orcid.org/0000-0002-3169-7395,4 Diego Mantovani,2 Francesco Michelotti1
1Sapienza Univ. di Roma (Italy) 2Univ. Laval (Canada) 3Fraunhofer-Institut für Angewandte Optik und Feinmechanik IOF (Germany) 4Istituto di Fisica Applicata "Nello Carrara" (Italy)
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The study of the interaction of fibronectin and phosphorylcholine molecules with surfaces is of high relevance to understand the biological performance of bioactive coatings. To accomplish this task, one-dimensional photonic crystals supporting Bloch surface waves were interrogated in label-free and enhanced fluorescence operation modes. In particular, the enhanced fluorescence mode offers the possibility to confirm the presence of proteins with a sharp improvement of the resolution. Bioactive coatings based on fibronectin/ phosphorylcholine have thus the potential to not only enhance the body acceptance of implanted devices, but also extend the lifetime of such devices.
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Alberto Sinibaldi, Vanessa Montano-Machado, Norbert Danz, Peter Munzert, Francesco Chiavaioli, Diego Mantovani, Francesco Michelotti, "Real-time monitoring of bioactive coating growth by means of Bloch surface wave biosensors," Proc. SPIE PC11979, Frontiers in Biological Detection: From Nanosensors to Systems XIV, PC1197908 (4 March 2022); https://doi.org/10.1117/12.2623478