Bond-selective intensity diffraction tomography (Conference Presentation)

Jian Zhao; Alex Matlock; Lei Tian; Ji-Xin Cheng

doi:10.1117/12.2634377

4 October 2022 Bond-selective intensity diffraction tomography (Conference Presentation)

Jian Zhao, Alex Matlock, Lei Tian, Ji-Xin Cheng

Author Affiliations +

Proceedings Volume PC12203, Enhanced Spectroscopies and Nanoimaging 2022; PC122030K (2022) https://doi.org/10.1117/12.2634377
Event: SPIE Nanoscience + Engineering, 2022, San Diego, California, United States

Abstract

Label-free chemical volumetric imaging is highly desired for biomedical applications and material science. Here, we present bond-selective intensity diffraction tomography (BS-IDT) based on the integration of mid-infrared photothermal microscopy with the computational imaging technique. BS-IDT demonstrates high-speed (up to ~6Hz) and large field of view (~100µmx100µm) chemical 3D imaging and enables the mid-infrared fingerprint spectra extraction with high fidelity. The superior performance of BS-IDT is validated by volumetric hyperspectral chemical imaging on cancer cells and Caenorhabditis elegans.

Conference Presentation

Citation Download Citation

Jian Zhao, Alex Matlock, Lei Tian, and Ji-Xin Cheng "Bond-selective intensity diffraction tomography (Conference Presentation)", Proc. SPIE PC12203, Enhanced Spectroscopies and Nanoimaging 2022, PC122030K (4 October 2022); https://doi.org/10.1117/12.2634377

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