Polarization-sensitive optical coherence tomography (PS-OCT) is a promising tool for non-invasive skin imaging, with its capability for depth-resolved, high-resolution, fast, and polarization-sensitive imaging. Thirty volunteers are recruited for skin imaging on the palm, arm, forehead, and eye corner. A segmentation algorithm based on intensity images will segment the epidermis and dermis layers and also stratum corneum if applicable. Multi-contrast images, including phase retardation, local birefringence, and degree of polarization uniformity, will be obtained from different skin layers. Possible relationships between the optical properties and skin features including layered structure, collagen organization, melanin concertation, and skin roughness will be investigated.
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