17 March 2023Demonstration of a combined multispectral FLIm/ polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions.
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We report the development and characterization of a multispectral FLIm/ polarization-sensitive OCT intravascular imaging catheter system. This system targets the improved characterization of two key contributors to atherosclerosis disease development: inflammation and disruption of the extracellular matrix, by enabling the evaluation of biochemical signature, birefringence, and depolarization in addition to lesion morphology. We present key aspects of the system’s design and performance and highlight challenges associated with the development of intravascular imaging systems suitable for clinical translation.
Julien Bec,Xiangnan Zhou,Pelham Keahey,Martin Villiger,Brett Bouma, andLaura Marcu
"Demonstration of a combined multispectral FLIm/ polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions.", Proc. SPIE PC12355, Diagnostic and Therapeutic Applications of Light in Cardiology 2023, PC1235505 (17 March 2023); https://doi.org/10.1117/12.2649672
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Julien Bec, Xiangnan Zhou, Pelham Keahey, Martin Villiger, Brett Bouma, Laura Marcu, "Demonstration of a combined multispectral FLIm/ polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions.," Proc. SPIE PC12355, Diagnostic and Therapeutic Applications of Light in Cardiology 2023, PC1235505 (17 March 2023); https://doi.org/10.1117/12.2649672