Skin PDT dose-depth estimation for radiometric comparison of lamp and daylight sources (Conference Presentation)

Alberto J. Ruiz; Ethan P. M. LaRochelle; M. Shane Chapman; Kimberley S. Samkoe; Brian W. Pogue

doi:10.1117/12.2667821

17 March 2023 Skin PDT dose-depth estimation for radiometric comparison of lamp and daylight sources (Conference Presentation)

Alberto J. Ruiz, Ethan P. M. LaRochelle, M. Shane Chapman, Kimberley S. Samkoe, Brian W. Pogue

Author Affiliations +

Proceedings Volume PC12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI; PC1235909 (2023) https://doi.org/10.1117/12.2667821
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Skin-based photodynamic therapy (PDT) is used for the clinical treatment of actinic keratosis (AKs) and other skin lesions with continued expansion into the standard of care. Due to the spectral dependency of photosensitizer activation and skin optical fluence, there is a need for more accurate methods to estimate the delivered dose at depth from different PDT light sources and treatment regimens. Here, we present radiometric methods for calculating photosensitizer-effective fluence and dose at depth and determine differences between red-lamp, blue-lamp, and daylight-based PDT treatments.

Conference Presentation

Citation Download Citation

Alberto J. Ruiz, Ethan P. M. LaRochelle, M. Shane Chapman, Kimberley S. Samkoe, and Brian W. Pogue "Skin PDT dose-depth estimation for radiometric comparison of lamp and daylight sources (Conference Presentation)", Proc. SPIE PC12359, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXI, PC1235909 (17 March 2023); https://doi.org/10.1117/12.2667821

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