Our research investigates retinal pigmentary abnormalities in retinitis pigmentosa (RP) patients using a wide-field high-speed polarization diversity optical coherence tomography (PD-OCT) in a clinical setting. To account for the retinal curvature in the wide field-of-view, adaptive kernel-based spatial averaging is employed for degree-of-polarization-uniformity (DOPU) contrast formation with two complex OCT signals from two orthogonal polarization channels. In 7 patients diagnosed with RP, retinal pigment epithelium (RPE) melanin loss centered at the macula is compared to standard multimodal imaging techniques, including intensity-based OCT, fundus photography, and short-wavelength fundus autofluorescence images.
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