5-HT2A receptor agonism modifies neurovascular coupling and neuronal network activity in mice

Jonah A. Padawer-Curry; Joshua S. Siegel; Anmol Jarang; Ginger E. Nicol; Jordan G. McCall; Adam Q. Bauer

doi:10.1117/12.2648386

17 March 2023 5-HT2A receptor agonism modifies neurovascular coupling and neuronal network activity in mice

Jonah A. Padawer-Curry, Joshua S. Siegel, Anmol Jarang, Ginger E. Nicol, Jordan G. McCall, Adam Q. Bauer

Proceedings Volume PC12365, Neural Imaging and Sensing 2023; PC1236505 (2023) https://doi.org/10.1117/12.2648386
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Psychedelics, which effects appear to be mediated via seratonin-2A receptors(5-HT2AR), are a promising therapeutic. Recent human studies have shown drastic changes in functional network organization but may be confounded due to Serotonin’s vasoconstriction effects. We aimed to determine if 5-HT2AR agonism (via Lisuride), alone, differentially affect cortical neuronal and hemodynamic activity, functional connectivity (FC), and neurovascular coupling (NVC). Eight Thy1-jRGECO1a mice were imaged for 60-minutes under awake, resting-state conditions using wide-field optical imaging. Lisuride significantly reduced neuronal and hemodynamic bilateral FC and activity in a region- and frequency-band-specific manner. Furthermore, delayed NVC was observed. Results suggest 5-HT2AR agonism alters hemodynamic activity, FC and NVC. Future work will evaluate acute effects of commonly used psychedelics on brain function and differentiate hallucinatory vs non-hallucinatory 5-HT2A receptor activation.

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Jonah A. Padawer-Curry, Joshua S. Siegel, Anmol Jarang, Ginger E. Nicol, Jordan G. McCall, and Adam Q. Bauer "5-HT2A receptor agonism modifies neurovascular coupling and neuronal network activity in mice", Proc. SPIE PC12365, Neural Imaging and Sensing 2023, PC1236505 (17 March 2023); https://doi.org/10.1117/12.2648386

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KEYWORDS

Receptors

Neurovascular coupling

Hemodynamics

Brain

Neuroimaging

Calcium

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