A solid optical phantom recipe and tools based on upconverting nanoparticles for biomedical applications

Sanathana Konugolu-Venkata-Sekar; Gokhan Dumlupinar; Claudia Nunzia Guadagno; Jean S. Matias; Pranav Lanka; Chris K. W. Kho; Stefan Andresson-Engels

doi:10.1117/12.2650114

6 March 2023 A solid optical phantom recipe and tools based on upconverting nanoparticles for biomedical applications

Sanathana Konugolu-Venkata-Sekar, Gokhan Dumlupinar, Claudia Nunzia Guadagno, Jean S. Matias, Pranav Lanka, Chris K. W. Kho, Stefan Andresson-Engels

Author Affiliations +

Proceedings Volume PC12370, Design and Quality for Biomedical Technologies XVI; PC123700C (2023) https://doi.org/10.1117/12.2650114
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Phantoms play a critical role in the development of biophotonics techniques. There is currently a lack of solid phantoms relevant to the emerging field of upconverting nanoparticles (UCNP) for biophotonics application. This work intends to showcase a range of UCNP-based phantom models and manufacturing recipe to bridge the gap and accelerate the development of UCNP-based biophotonics applications. A total of 24 phantoms were classified into 4 different categories: homogeneous, multilayer, tumour inclusion and UCNP background phantoms were manufactured and an example use case was explored. The optical properties (absorption, reduced scattering and UCNP emission) of these phantoms were found to be stable over a period of 4 months with CV < 4%. With the recent advances in the use of UCNP for biophotonics, we believe our recipe and tools will play a pivotal role in the growth of the UCNP for biophotonics applications.

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Citation Download Citation

Sanathana Konugolu-Venkata-Sekar, Gokhan Dumlupinar, Claudia Nunzia Guadagno, Jean S. Matias, Pranav Lanka, Chris K. W. Kho, and Stefan Andresson-Engels "A solid optical phantom recipe and tools based on upconverting nanoparticles for biomedical applications", Proc. SPIE PC12370, Design and Quality for Biomedical Technologies XVI, PC123700C (6 March 2023); https://doi.org/10.1117/12.2650114

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