Multimodal image fusion of time-domain mesoscopic fluorescence molecular tomography and short wave infrared imaging for resolution enhancement

Luis Chavez; Shan Gao; Xavier Intes

doi:10.1117/12.2650544

6 March 2023 Multimodal image fusion of time-domain mesoscopic fluorescence molecular tomography and short wave infrared imaging for resolution enhancement

Luis Chavez, Shan Gao, Xavier Intes

Author Affiliations +

Proceedings Volume PC12371, Multimodal Biomedical Imaging XVIII; PC123710B (2023) https://doi.org/10.1117/12.2650544
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The novel Time-Domain Mesoscopic Fluorescence Molecular Tomography (TD-MFMT) imaging modality is aimed to resolve intra-tumoral heterogeneity and monitoring target engagement at the mesoscopic regime; however, its spatial resolution is limited by the scan strategy employed for imaging. Imaging in the Short-Wave Infrared (SWIR) can improve resolution due to reduced scattering effect. We therefore implement data-fusion of low-resolution fluorescence lifetime images with high-resolution SWIR intensity images via deep learning (DL). This approach was validated through phantom study where results show resolution enhancement of fluorescence lifetime imaging in scattering media, demonstrating potential for expansion to preclinical studies.

Conference Presentation

Citation Download Citation

Luis Chavez, Shan Gao, and Xavier Intes "Multimodal image fusion of time-domain mesoscopic fluorescence molecular tomography and short wave infrared imaging for resolution enhancement", Proc. SPIE PC12371, Multimodal Biomedical Imaging XVIII, PC123710B (6 March 2023); https://doi.org/10.1117/12.2650544

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