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We present results of rectal cancer treatment response assessment using co-registered ultrasound and photoacoustic imaging from over 20 in vivo patients. We develop a deep learning model based on co-registered dual-modality images with individualized prior information. Compared to models using only ultrasound images, our model identifies complete treatment responders with significantly higher accuracy. We achieve a 3-class classification accuracy (normal, cancer, and image artifact) of 89.1±0.8%. To facilitate surgeons’ decision-making, we generate localized hotspots to indicate suspicious cancer regions based on model predictions. We conclude that the addition of photoacoustic imaging to conventional ultrasound improves treatment response assessment.
Yixiao Lin,Sitai Kou,Haolin Nie, andQuing Zhu
"Deep learning based on co-registered ultrasound and photoacoustic imaging improves assessment of rectal cancer chemoradiotherapy response", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123790C (9 March 2023); https://doi.org/10.1117/12.2649328
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Yixiao Lin, Sitai Kou, Haolin Nie, Quing Zhu, "Deep learning based on co-registered ultrasound and photoacoustic imaging improves assessment of rectal cancer chemoradiotherapy response," Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123790C (9 March 2023); https://doi.org/10.1117/12.2649328